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. 2015 Sep;95(12):2482-6.
doi: 10.1002/jsfa.6978. Epub 2014 Nov 24.

Anti-inflammatory Activity of Mushroom-Derived Hispidin Through Blocking of NF-κB Activation

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Anti-inflammatory Activity of Mushroom-Derived Hispidin Through Blocking of NF-κB Activation

Hong Jun Shao et al. J Sci Food Agric. .

Abstract

Background: Hispidin, a polyphenol compound mainly derived from the valuable medicinal mushroom Phellinus species, has been found to possess distinct biological effects. However, the anti-inflammatory potential of hispidin still remains uncharacterized.

Results: In this study, the effects of hispidin on activation of nuclear factor kappa B (NF-κB) and the subsequent production of inducible nitric oxide synthase (iNOS) were determined in the lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cells. Our data indicated that hispidin inhibits transcriptional activity of NF-κB in a dose-dependent manner. Hispidin also attenuated LPS-induced NF-κB nuclear translocation and associated inhibitor of kappa B (IκB-α) degradation. Furthermore, hispidin deceased iNOS protein expression and the generation of reactive oxygen species (ROS) in the LPS-induced cells, but did not affect phosphorylation of mitogen-activated protein kinases.

Conclusion: These findings suggest that hispidin exhibits anti-inflammatory activity through suppressing ROS mediated NF-κB pathway in mouse macrophage cells.

Keywords: NF-κB; ROS; anti-inflammation; hispidin.

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