Appreciating force and shape—the rise of mechanotransduction in cell biology

Nat Rev Mol Cell Biol. 2014 Dec;15(12):825-33. doi: 10.1038/nrm3903. Epub 2014 Oct 30.


Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility—for example, during cell-matrix adhesion development—through the signalling process of mechanotransduction.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Cell Biology / history*
  • Extracellular Matrix / physiology
  • History, 20th Century
  • History, 21st Century
  • Mechanotransduction, Cellular*