Nuclear actin activates human transcription factor genes including the OCT4 gene

Biosci Biotechnol Biochem. 2015;79(2):242-6. doi: 10.1080/09168451.2014.972332. Epub 2014 Oct 30.


RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.

Keywords: OCT4; nuclear actin; transcription; transcription microarray.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cell Nucleus / metabolism*
  • HeLa Cells
  • Humans
  • Octamer Transcription Factor-3 / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Transcription, Genetic / genetics
  • Transcriptional Activation*


  • Actins
  • Octamer Transcription Factor-3
  • POU5F1 protein, human