PDZRN3/LNX3 is a novel target of human papillomavirus type 16 (HPV-16) and HPV-18 E6

J Virol. 2015 Jan 15;89(2):1439-44. doi: 10.1128/JVI.01743-14. Epub 2014 Oct 29.


High-risk human papillomavirus (HPV) E6 proteins have a C-terminal PDZ binding motif through which they bind, and target for proteasome-mediated degradation, a number of PDZ-containing cellular targets. Recent studies have suggested that the RING-containing ubiquitin-protein ligase PDZRN3 might also be an HPV E6 target. In this analysis, we show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the HPV life cycle and differentiation-related STAT signaling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Female
  • Host-Pathogen Interactions*
  • Human papillomavirus 16 / physiology*
  • Human papillomavirus 18 / physiology*
  • Humans
  • Oncogene Proteins, Viral / metabolism*
  • Proteasome Endopeptidase Complex / metabolism
  • Proteolysis
  • Repressor Proteins / metabolism*
  • Ubiquitin-Protein Ligases


  • Carrier Proteins
  • DNA-Binding Proteins
  • E6 protein, Human papillomavirus type 16
  • E6 protein, Human papillomavirus type 18
  • Oncogene Proteins, Viral
  • Repressor Proteins
  • PDZRN3 protein, human
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex