Cyclin C surprises in tumour suppression

Nat Cell Biol. 2014 Nov;16(11):1031-3. doi: 10.1038/ncb3055.


Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cyclin C / metabolism*
  • Cyclin-Dependent Kinases / metabolism*
  • Humans
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Receptor, Notch1 / metabolism*


  • Cyclin C
  • Receptor, Notch1
  • Cyclin-Dependent Kinases