A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp

Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478.


Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, popularly used for complementary cancer therapy. GTs are lanostane-tetracyclic triterpenes. They have been reported to possess anti-tumor, anti-inflammation, antioxidant, antimicrobial and blood fat reducing effects. To date, 316 GTs have been found and their similar chemical structures have proved difficult to elucidate. This paper compiles 316 naturally occurring triterpenes from Ganoderma based on the literature published through January 2013 along with their structures, physiological activities and 13C-NMR spectral data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / pharmacology*
  • Ganoderma / chemistry*
  • Humans
  • Mice
  • Structure-Activity Relationship
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*


  • Drugs, Chinese Herbal
  • Triterpenes