doi: 10.1126/science.2536188.
Transneuronal transfer of herpes virus from peripheral nerves to cortex and brainstem
Affiliations
- PMID: 2536188
- DOI: 10.1126/science.2536188
Item in Clipboard
Transneuronal transfer of herpes virus from peripheral nerves to cortex and brainstem
Science.
.
Abstract
The transneuronal transfer of neurotropic viruses may represent an effective tool for tracing chains of connected neurons because replication of virus in the recipient neurons after transfer amplifies the "tracer signal." Herpes simplex virus type 1 was transferred transneuronally from forelimb and hindlimb nerves of rats to the cortical and brainstem neurons that project to the spinal enlargements to which the nerves receiving injections are connected. This transneuronal transfer of herpes simplex virus type 1 from peripheral nerves has the potential to be used to identify neurons in the brain that are related transsynaptically to different nerves and muscles.
Similar articles
-
Transneuronal transfer of herpes simplex virus type 1 (HSV 1) from mixed limb nerves to the CNS. I. Sequence of transfer from sensory, motor, and sympathetic nerve fibres to the spinal cord.J Comp Neurol. 1992 Dec 22;326(4):527-48. doi: 10.1002/cne.903260404. J Comp Neurol. 1992. PMID: 1336502
-
Neuron to neuron transmission of herpes simplex virus. Transport of virus from skin to brainstem nuclei.J Neurol Sci. 1982 Apr;54(1):149-56. doi: 10.1016/0022-510x(82)90227-1. J Neurol Sci. 1982. PMID: 6281393
-
Direction of transneuronal transport of herpes simplex virus 1 in the primate motor system is strain-dependent.Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8048-51. doi: 10.1073/pnas.88.18.8048. Proc Natl Acad Sci U S A. 1991. PMID: 1654557 Free PMC article.
-
Viruses as transneuronal tracers.Trends Neurosci. 1990 Feb;13(2):71-5. doi: 10.1016/0166-2236(90)90071-h. Trends Neurosci. 1990. PMID: 1690933 Review.
-
[Latency of herpes simplex virus. Current knowledge].Enferm Infecc Microbiol Clin. 1991 Mar;9(3):172-6. Enferm Infecc Microbiol Clin. 1991. PMID: 1650583 Review. Spanish. No abstract available.
Cited by
-
Immunoperoxidase tracing of Junin virus neural route after footpad inoculation.Arch Virol. 1992;122(1-2):13-22. doi: 10.1007/BF01321114. Arch Virol. 1992. PMID: 1309637 Free PMC article.
-
Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience.Annu Rev Genet. 2016 Nov 23;50:571-594. doi: 10.1146/annurev-genet-120215-035011. Epub 2016 Oct 6. Annu Rev Genet. 2016. PMID: 27732792 Free PMC article. Review.
-
Labeling Dual Presynaptic Inputs using cFork Anterograde Tracing System.Exp Neurobiol. 2020 Jun 30;29(3):219-229. doi: 10.5607/en20006. Exp Neurobiol. 2020. PMID: 32624506 Free PMC article.
-
Techniques to Render Dendritic Spines Visible in the Microscope.Adv Neurobiol. 2023;34:69-102. doi: 10.1007/978-3-031-36159-3_2. Adv Neurobiol. 2023. PMID: 37962794
-
Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms.J Comp Neurol. 2015 Aug 1;523(11):1639-63. doi: 10.1002/cne.23761. Epub 2015 Apr 2. J Comp Neurol. 2015. PMID: 25688551 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
