On the possibility of pleiotropic monogenic control of hereditary polyposis and primary cancer of the colon

Am J Hum Genet. 1989 Feb;44(2):191-7.

Abstract

The results of the segregation analysis of hereditary adenomatous polyposis and primary cancer of the colon are given, taking into account the age-dependent manifestation of genotypes and the specificity of pedigree sampling. The results are used for testing the hypothesis of pleiotropic monogenic control of these two colon pathologies.

MeSH terms

  • Adenomatous Polyposis Coli / genetics*
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Child
  • Colonic Neoplasms / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic*
  • Neoplastic Syndromes, Hereditary / genetics*
  • Pedigree
  • Probability