On the possibility of pleiotropic monogenic control of hereditary polyposis and primary cancer of the colon

E K Ginsburg; T I Axenovich; B A Altshouler; M D Bazhenova

On the possibility of pleiotropic monogenic control of hereditary polyposis and primary cancer of the colon

Am J Hum Genet. 1989 Feb;44(2):191-7.

Authors

E K Ginsburg¹, T I Axenovich, B A Altshouler, M D Bazhenova

Affiliation

¹ Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk.

PMID: 2536218
PMCID: PMC1715412

Abstract

The results of the segregation analysis of hereditary adenomatous polyposis and primary cancer of the colon are given, taking into account the age-dependent manifestation of genotypes and the specificity of pedigree sampling. The results are used for testing the hypothesis of pleiotropic monogenic control of these two colon pathologies.

MeSH terms

Adenomatous Polyposis Coli / genetics*
Adolescent
Adult
Age Factors
Aged
Child
Colonic Neoplasms / genetics*
Female
Humans
Male
Middle Aged
Models, Genetic*
Neoplastic Syndromes, Hereditary / genetics*
Pedigree
Probability