The effects of fish oil capsules and vitamin B1 tablets on duration and severity of dysmenorrhea in students of high school in Urmia-Iran

Glob J Health Sci. 2014 Sep 18;6(7 Spec No):124-9. doi: 10.5539/gjhs.v6n7p124.


Aims: The purpose of this study is the comparison of the effect of vitamin B1 and fish oil with together on severity and duration of dysmenorrhea, and if it is effective, we can administrative both of them with less complication to compare with other chemical drugs which has many disadvantages.

Study design: High school of Urmia city, between March 2008 and June 2008.

Methodology: This study has a double-blind clinical trial design.240 high school female students with dysmenorrhea by a randomized Method were followed up in a double-blind, randomized, placebo-controlled study by dividing into four groups with 60 members. The daily supplement was vit B1 (100 mg/day and fish oil pearl 500 mg/day), taken as a single dose starting at the beginning of the menstrual cycle and continued for 2 consecutive months.

Results: Intensity of pain in three experimental groups (Vit B1, fish oil and both of them) had significant difference comparing placebo group and intensity of pain had reduced. (p<0.001), (p=0.018), (p<0.001) VS in placebo group (p=0.79). Duration of pain had significantly reduced in all three experimental groups compared with placebo group. (p=0.004), (p=0.008), (p<0.001) VS in placebo group (p=0.32). In all of drugs, results (mean) was better at the end of the second month than the first month.

Conclusion: Fish oil and vit B1 effects on treatment of primary dysmenorrhea were similar, but vit B1 has less complications and it was more acceptable. We mixed them and compared its results with vit B1, fish oil and placebo separately. Pain duration is the least in Vitamin B1 tablets compare with the others, but its duration was minimum in complex of Vitamin B1 tablets and fish oil capsules. Due to good effects of vitamin B1 and fish oil on symptoms of dysmenorrhea, using of them is suggested.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Dietary Supplements*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Dysmenorrhea / drug therapy*
  • Female
  • Fish Oils / administration & dosage
  • Fish Oils / therapeutic use*
  • Humans
  • Iran
  • Pain Measurement
  • Thiamine / administration & dosage
  • Thiamine / therapeutic use*


  • Fish Oils
  • Thiamine