Correlations between brachial endothelial function and cardiovascular risk factors: a survey of 2,511 Chinese subjects

J Thorac Dis. 2014 Oct;6(10):1441-51. doi: 10.3978/j.issn.2072-1439.2014.08.04.


Objective: We examined the relationship of several cardiovascular risk factors (CVRF) to brachial artery flow-mediated dilatation (FMD) in Chinese subjects.

Methods: This was a cross-sectional study. In 2,511 Chinese adults (age 46.86±9.52 years, 1,891 men and 620 women) recruited from people who underwent health screening at The Third Xiangya Hospital, patients' CVRF [age, body mass index (BMI), waist circumference (WC), blood pressure (BP), cholesterol parameters, creatinine (Cr), uric acid (UA), glucose level and smoking] and prevalence of present disease (hypertension, diabetes mellitus, coronary heart disease and hyperlipidemia) were investigated.

Results: Multivariate analysis revealed that FMD negative correlated with age (β=-0.29, P<0.001), gender (β=-0.12, P<0.001), BMI (β=-0.12, P=0.001), WC (β=-0.10, P=0.011), systolic BP (SBP) (β=-0.12, P<0.001), fasting glucose (β=-0.04, P=0.009), total cholesterol (TC) (β=-0.04, P=0.014), smoking (β=-0.05, P=0.003), and baseline brachial artery diameter (β=-0.35, P<0.001). FMD decreased with increasing age in both genders. In women, FMD was higher than men and age-related decline in FMD was steepest after age 40; FMD was similar in men above 55 years old.

Conclusions: In Chinese subjects, FMD may be a usefully marker of CVRF. Age, gender, BMI, WC, SBP, fasting glucose, TC, smoking, and baseline brachial artery diameter were independent variables related to the impairment of FMD. The influence of CVRF on endothelial function is more in women than men.

Keywords: Endothelial function; brachial artery flow-mediated dilatation (FMD); cardiovascular risk factors (CVRF).