Hypoxic Signaling During Tissue Repair and Regenerative Medicine

Int J Mol Sci. 2014 Oct 31;15(11):19791-815. doi: 10.3390/ijms151119791.


In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in wound healing, knowledge about the function of HIF-2α in wound healing is lacking. This review focuses on the function of HIF-1α and HIF-2α in microvascular network formation, wound healing, and therapy strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Basic Helix-Loop-Helix Transcription Factors / chemistry
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Humans
  • Hypoxia*
  • Hypoxia-Inducible Factor-Proline Dioxygenases / metabolism
  • Neovascularization, Physiologic
  • Regenerative Medicine*
  • Signal Transduction*
  • Tissue Engineering*
  • Wound Healing


  • Basic Helix-Loop-Helix Transcription Factors
  • Hypoxia-Inducible Factor-Proline Dioxygenases