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Comparative Study
. 2014;77(9):3-7.

[Effect of S-amlodipine Nicotinate on the Cerebral Circulation in Rats Under Conditions of Ischemic and Hemorrhagic Brain Injury]

[Article in Russian]
  • PMID: 25365862
Comparative Study

[Effect of S-amlodipine Nicotinate on the Cerebral Circulation in Rats Under Conditions of Ischemic and Hemorrhagic Brain Injury]

[Article in Russian]
T S Gan'shina et al. Eksp Klin Farmakol. .

Abstract

We have performed a comparative study of the effects of S-amlodipine nicotinate and nimodipine on the local cerebral blood flow were studied in intact rats and those with model ischemic and hemorrhagic brain injury. It is established that S-amlodipine nicotinate produces a somewhat more pronounced enhancement of cerebral blood flow in rats with ischemic and hemorrhagic brain injury than in intact animals. In addition, S-amlodipine nicotinate significantly exceed nimodipine with respect to cerebrovascular activity in rats with brain pathology of both ischemic and hemorrhagic nature.

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