Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix

Cancer. 1989 Mar 1;63(5):897-900. doi: 10.1002/1097-0142(19890301)63:5<897::aid-cncr2820630517>;2-w.


Cases of invasive carcinoma of the uterine cervix were analyzed to determine whether the presence or absence of human papillomavirus (HPV) DNA in the neoplasms was a contributing factor to their outcome. The presence of HPV DNA was evaluated using in situ hybridization on formalin-fixed, paraffin-embedded tissue sections. Eighty-five patients with cervical carcinoma who had been surgically evaluated were included in the study. Data from these patients was analyzed retrospectively to determine survival, recurrence, presence of nodal metastases, tumor grade, mode of therapy, peritoneal fluid cytologic results, and age in relation to presence or absence of HPV DNA. No significant statistical differences were found between the HPV-16-positive, HPV-18-positive, and HPV DNA-negative patients.

MeSH terms

  • Adenocarcinoma / microbiology
  • Adult
  • Carcinoma, Adenoid Cystic / microbiology
  • Carcinoma, Squamous Cell / microbiology
  • DNA, Viral / analysis*
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Nucleic Acid Hybridization
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Prognosis
  • Retrospective Studies
  • Uterine Cervical Neoplasms / microbiology*
  • Uterine Cervical Neoplasms / mortality
  • Uterine Cervical Neoplasms / pathology


  • DNA, Viral