Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

Acta Neuropathol. 2015 Jan;129(1):157-9. doi: 10.1007/s00401-014-1360-5. Epub 2014 Nov 4.

Authors

Manuel Schweighauser¹, Mehtap Bacioglu, Sarah K Fritschi, Derya R Shimshek, Philipp J Kahle, Yvonne S Eisele, Mathias Jucker

Affiliation

¹ German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.

PMID: 25367384
DOI: 10.1007/s00401-014-1360-5

No abstract available

Publication types

Letter

MeSH terms

Animals
Brain Stem / pathology
Brain Stem / physiopathology*
Dentate Gyrus / pathology
Dentate Gyrus / physiopathology*
Female
Formaldehyde*
Immunoblotting
Immunohistochemistry
Mice, Transgenic
Neurodegenerative Diseases / pathology
Neurodegenerative Diseases / physiopathology*
Proteostasis Deficiencies / pathology
Proteostasis Deficiencies / physiopathology*
Survival Analysis
Tissue Extracts
Tissue Fixation*
alpha-Synuclein / genetics
alpha-Synuclein / metabolism*

Substances

SNCA protein, human
Snca protein, mouse
Tissue Extracts
alpha-Synuclein
Formaldehyde