The focally amplified lncRNA FAL1 exhibits oncogenic activity

Cancer Discov. 2014 Nov;4(11):1253. doi: 10.1158/2159-8290.CD-RW2014-202. Epub 2014 Sep 25.

Abstract

FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21.

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism
  • DNA Copy Number Variations
  • Humans
  • Mice
  • Mitogen-Activated Protein Kinase 7 / metabolism
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • RNA, Long Noncoding*

Substances

  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • RNA, Long Noncoding
  • MAPK7 protein, human
  • Mitogen-Activated Protein Kinase 7