Periocular intralymphatic histiocytosis or localized Melkersson-Rosenthal syndrome?

J Cutan Pathol. 2015 Apr;42(4):289-94. doi: 10.1111/cup.12419. Epub 2015 Feb 3.


We describe three cases of periocular edema with histopathologic features of intralymphatic histiocytosis without extravascular granulomas. All were elderly males with no other significant medical problems. Previous reports of periocular Melkersson-Rosenthal syndrome are identical clinically, and some reports show illustrations of intralymphatic histiocytosis histopathologically, in addition to other features typical of the syndrome. Given the lack of associated diseases or other features of the Melkersson-Rosenthal triad, some of these cases may be better defined as periocular intralymphatic histiocytosis.

Keywords: Melkersson-Rosenthal syndrome; histiocytes; intravascular; lymphatic; periocular.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Eyelid Diseases / drug therapy
  • Eyelid Diseases / pathology*
  • Eyelid Diseases / surgery
  • Histiocytes / pathology
  • Histiocytosis / diagnosis*
  • Histiocytosis / pathology
  • Humans
  • Lymphatic System / pathology
  • Male
  • Melkersson-Rosenthal Syndrome / diagnosis*
  • Melkersson-Rosenthal Syndrome / pathology
  • Middle Aged