Vitamin D, vascular calcification and mortality among alcoholics

Alcohol Alcohol. 2015 Jan;50(1):18-23. doi: 10.1093/alcalc/agu076. Epub 2014 Nov 3.


Aims: To analyze the relationship between low vitamin D levels and mortality among alcoholics.

Methods: One hundred twenty-eight alcoholic patients admitted to our hospital were followed up as outpatients. Nutritional status was evaluated measuring percentages of fat and lean mass in different body compartments.

Results: Lower vitamin D levels were observed in patients with worse liver function. Vitamin D was lower in patients with lower total lean mass (Z = 2.8, P = 0.005), but it was not related to fat mass. There was a significant trend to higher long-term mortality among non-cirrhotics with vitamin D levels below 30 ng/ml, although Cox's regression model revealed that only Child score and age were independently related to mortality.

Conclusion: Vitamin D deficiency is common among alcoholic patients and is associated with low lean mass and liver dysfunction. Among non-cirrhotics, serum vitamin D levels below 30 ng/ml are associated with a greater long-term mortality.

MeSH terms

  • Alcoholism / blood
  • Alcoholism / mortality*
  • Alcoholism / pathology
  • Bilirubin / blood
  • Body Composition
  • Body Mass Index
  • Female
  • Humans
  • Liver Cirrhosis, Alcoholic / blood
  • Liver Cirrhosis, Alcoholic / mortality
  • Liver Cirrhosis, Alcoholic / pathology
  • Male
  • Middle Aged
  • Nutritional Status
  • Proportional Hazards Models
  • Serum Albumin / analysis
  • Vascular Calcification / blood
  • Vascular Calcification / mortality*
  • Vitamin D / blood*


  • Serum Albumin
  • Vitamin D
  • Bilirubin