MicroRNAs meet calcium: joint venture in ER proteostasis

Sci Signal. 2014 Nov 4;7(350):re11. doi: 10.1126/scisignal.2005671.

Abstract

The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca(2+) concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca(2+) handling and storage and maintain ER homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Disease Models, Animal
  • Disulfides
  • Endoplasmic Reticulum / metabolism*
  • Gene Expression Regulation*
  • Homeostasis
  • Humans
  • Ions
  • Mice
  • MicroRNAs / metabolism*
  • Protein Folding
  • Unfolded Protein Response

Substances

  • Disulfides
  • Ions
  • MicroRNAs
  • Calcium