An expanding universe of mRNA modifications

Nat Struct Mol Biol. 2014 Nov;21(11):945-6. doi: 10.1038/nsmb.2911.

Abstract

The fate of mRNA can be regulated by internal base modifications, with the currently known modified bases being N6-methyladenosine, 5-methylcytosine, and inosine. Three new studies show that yeast and human mRNA also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.

MeSH terms

  • 5-Methylcytosine / metabolism
  • Adenosine / analogs & derivatives
  • Adenosine / metabolism
  • Humans
  • Inosine / metabolism
  • Pseudouridine / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*

Substances

  • RNA, Messenger
  • Pseudouridine
  • N(6)-methyladenosine
  • Inosine
  • 5-Methylcytosine
  • Adenosine