Opposite effects of estrogen and catecholestrogen on hormone-sensitive breast cancer cell growth and differentiation

Mol Cell Endocrinol. 1989 Feb;61(2):239-46. doi: 10.1016/0303-7207(89)90135-4.

Abstract

Catecholestrogens and especially 2-hydroxyestrone (2OH-E1) are estradiol metabolites locally formed in breast cancer cells. The present study demonstrates that the two parent compounds, estradiol (E2) and its metabolite 2OH-E1, exert opposite effects on hormone-sensitive breast cancer cell growth assessed by cell counts and transferrin receptor levels, and also on cell differentiation assessed by secreted proteins such as alpha-lactalbumin and gross cystic disease fluid protein (GCDFP-15). The present findings may highlight estradiol regulation in hormone-sensitive breast cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / enzymology
  • Breast Neoplasms / metabolism*
  • Cells, Cultured
  • Estradiol / pharmacology*
  • Estrogens, Catechol / pharmacology*
  • Estrone / analogs & derivatives*
  • Female
  • Humans
  • Hydroxyestrones / pharmacology*
  • Receptors, Progesterone / analysis
  • Receptors, Progesterone / biosynthesis
  • Receptors, Transferrin / analysis
  • Receptors, Transferrin / metabolism

Substances

  • Estrogens, Catechol
  • Hydroxyestrones
  • Receptors, Progesterone
  • Receptors, Transferrin
  • Estrone
  • Estradiol
  • 2-hydroxyestrone