Tight coordination of growth and differentiation between germline and soma provides robustness for drosophila egg development

Cell Rep. 2014 Oct 23;9(2):531-41. doi: 10.1016/j.celrep.2014.09.035. Epub 2014 Oct 16.

Abstract

Organs often need to coordinate the growth of distinct tissues during their development. Here, we analyzed the coordination between germline cysts and the surrounding follicular epithelium during Drosophila oogenesis. Genetic manipulations of the growth rate of both germline and somatic cells influence the growth of the other tissue accordingly. Growth coordination is therefore ensured by a precise, two-way, intrinsic communication. This coordination tends to maintain constant epithelial cell shape, ensuring tissue homeostasis. Moreover, this intrinsic growth coordination mechanism also provides cell differentiation synchronization. Among growth regulators, PI3-kinase and TORC1 also influence differentiation timing cell-autonomously. However, these two pathways are not regulated by the growth of the adjacent tissue, indicating that their function reflects an extrinsic and systemic influence. Altogether, our results reveal an integrated and particularly robust mechanism ensuring the spatial and temporal coordination of tissue size, cell size, and cell differentiation for the proper development of two adjacent tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult Stem Cells / cytology*
  • Adult Stem Cells / metabolism
  • Animals
  • Cell Differentiation*
  • Cell Proliferation
  • Drosophila / metabolism
  • Drosophila / physiology*
  • Epithelial Cells / cytology*
  • Epithelial Cells / metabolism
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / metabolism
  • Oogenesis*
  • Phosphatidylinositol 3-Kinases / metabolism
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Multiprotein Complexes
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases