Ubiquitination in disease pathogenesis and treatment

Nat Med. 2014 Nov;20(11):1242-53. doi: 10.1038/nm.3739. Epub 2014 Nov 6.


Ubiquitination is crucial for a plethora of physiological processes, including cell survival and differentiation and innate and adaptive immunity. In recent years, considerable progress has been made in the understanding of the molecular action of ubiquitin in signaling pathways and how alterations in the ubiquitin system lead to the development of distinct human diseases. Here we describe the role of ubiquitination in the onset and progression of cancer, metabolic syndromes, neurodegenerative diseases, autoimmunity, inflammatory disorders, infection and muscle dystrophies. Moreover, we indicate how current knowledge could be exploited for the development of new clinical therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Disease*
  • Genomic Instability
  • Humans
  • Protein Stability
  • Signal Transduction
  • Ubiquitin / metabolism
  • Ubiquitination / drug effects*


  • Ubiquitin