Topical anesthesia or oral dextrose for the relief of pain in screening for retinopathy of prematurity: a randomized controlled double-blinded trial

J Trop Pediatr. 2015 Feb;61(1):20-4. doi: 10.1093/tropej/fmu058. Epub 2014 Nov 5.

Abstract

Objective: Compare efficacy of 0.5% proparacaine eye drops and oral 25% dextrose in reducing pain during screening for retinopathy of prematurity (ROP).

Patients and methods: Double-blinded randomized controlled trial. Twenty eligible babies were randomized. Group I received 0.5% proparacaine eye drops at first ROP screening, while Group II received 25% dextrose orally. At second examination, babies received no intervention. Pain was assessed using Premature Infant Pain Profile (PIPP) score.

Results: The mean ( ± SD) PIPP during procedure in Group I were 15.5 ± 2.06 and 14 ± 2.4 at first and second screening (p = 0.259). The mean ( ± SD) PIPP in Group II were 14.2 ± 1. 8 and 14.9 ± 2.5 at the first and second screening (p = 0.428). Differences were not statistically significant. The PIPP scores of Group I and Group II at the first screening were also not significantly different (p = 0.165).

Conclusion: ROP screening causes moderate to severe pain and neither proparacaine nor dextrose is an effective analgesic.

Keywords: PIPP; ROP screening; dextrose; pain; proparacaine.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Anesthetics, Local / administration & dosage*
  • Double-Blind Method
  • Eye Pain / prevention & control*
  • Glucose / administration & dosage*
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intensive Care Units, Neonatal
  • Neonatal Screening*
  • Pain Measurement
  • Propoxycaine / administration & dosage*
  • Retinopathy of Prematurity / diagnosis*
  • Treatment Outcome

Substances

  • Anesthetics, Local
  • proxymetacaine
  • Propoxycaine
  • Glucose