A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

Benjamin D Fairbanks; Michael P Schwartz; Alexandra E Halevi; Charles R Nuttelman; Christopher N Bowman; Kristi S Anseth

doi:10.1002/adma.200901808

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

Adv Mater. 2009 Dec 28;21(48):5005-5010. doi: 10.1002/adma.200901808. Epub 2009 Oct 7.

Authors

Benjamin D Fairbanks¹, Michael P Schwartz¹, Alexandra E Halevi¹, Charles R Nuttelman¹, Christopher N Bowman¹, Kristi S Anseth²

Affiliations

¹ Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
² Department of Chemical and Biological Engineering and the Howard Hughes Medical Institute University of Colorado Boulder, CO 80309-0424 (USA).

Abstract

Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.

Keywords: hydrogels; photochemistry; polymeric materials; stimuli-responsive materials; tissue engineering.

Abstract

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