Abstract
The authors report a case of malignant lymphoma, small lymphocytic type, involving the lymphoid stroma of a Warthin's tumor of the parotid gland. This was confirmed by the presence of a monoclonal immunoglobulin heavy chain gene rearrangement, demonstrated by Southern blot hybridization of DNA extracted from paraffin-embedded tissue. Similar techniques showed only germline immunoglobulin gene bands in two control cases of Warthin's tumor.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenolymphoma / genetics
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Adenolymphoma / pathology*
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DNA / analysis*
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DNA / genetics
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DNA Restriction Enzymes
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Female
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Gene Rearrangement
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Histological Techniques
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Humans
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Lymphoma / genetics
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Lymphoma / pathology*
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Middle Aged
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Neoplasms, Multiple Primary*
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Nucleic Acid Hybridization
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Parotid Neoplasms / genetics
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Parotid Neoplasms / pathology*
Substances
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DNA
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DNA Restriction Enzymes