Warthin's tumor with malignant lymphoma. DNA analysis of paraffin-embedded tissue

Am J Clin Pathol. 1989 Mar;91(3):341-4. doi: 10.1093/ajcp/91.3.341.


The authors report a case of malignant lymphoma, small lymphocytic type, involving the lymphoid stroma of a Warthin's tumor of the parotid gland. This was confirmed by the presence of a monoclonal immunoglobulin heavy chain gene rearrangement, demonstrated by Southern blot hybridization of DNA extracted from paraffin-embedded tissue. Similar techniques showed only germline immunoglobulin gene bands in two control cases of Warthin's tumor.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenolymphoma / genetics
  • Adenolymphoma / pathology*
  • DNA / analysis*
  • DNA / genetics
  • DNA Restriction Enzymes
  • Female
  • Gene Rearrangement
  • Histological Techniques
  • Humans
  • Lymphoma / genetics
  • Lymphoma / pathology*
  • Middle Aged
  • Neoplasms, Multiple Primary*
  • Nucleic Acid Hybridization
  • Parotid Neoplasms / genetics
  • Parotid Neoplasms / pathology*


  • DNA
  • DNA Restriction Enzymes