Alternative splicing of human insulin receptor messenger RNA

Biochem Biophys Res Commun. 1989 Feb 28;159(1):312-6. doi: 10.1016/0006-291x(89)92439-x.

Abstract

The polymerase chain reaction has been used to examine alternative splicing of human insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11, generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-terminal end of the insulin-binding alpha-subunit. This process appears to be tissue-specific and, in addition, may be developmentally regulated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Composition
  • Base Sequence
  • Carcinoma, Hepatocellular / metabolism
  • Cloning, Molecular
  • Exons
  • Gene Amplification
  • Humans
  • Liver / embryology
  • Liver / metabolism
  • Liver Neoplasms / metabolism
  • Molecular Sequence Data
  • RNA Splicing*
  • RNA, Messenger / genetics*
  • Receptor, Insulin / genetics*
  • Recombinant Proteins
  • Tissue Distribution
  • Transcription, Genetic
  • Tumor Cells, Cultured

Substances

  • RNA, Messenger
  • Recombinant Proteins
  • Receptor, Insulin

Associated data

  • GENBANK/M24555