The major human rhinovirus receptor is ICAM-1

Cell. 1989 Mar 10;56(5):839-47. doi: 10.1016/0092-8674(89)90688-0.


The major human rhinovirus receptor has been identified with monoclonal antibodies that inhibit rhinovirus infection. These monoclonal antibodies recognize a 95 kd cell surface glycoprotein on human cells and on mouse transfectants expressing a rhinovirus binding phenotype. Purified 95 kd protein binds to rhinovirus in vitro. Protein sequence from the 95 kd protein showed an identity with that of intercellular adhesion molecule-1 (ICAM-1); a cDNA clone obtained from mouse transfectants expressing the rhinovirus receptor had essentially the same sequence as ICAM-1. Thus, the major human rhinovirus receptor is ICAM-1. The gene for this receptor maps to human chromosome 19, which also contains the genes for a number of other picornavirus receptors.

MeSH terms

  • Alkaloids / pharmacology
  • Amino Acid Sequence
  • Antibodies, Monoclonal / immunology
  • Antigens, Surface / genetics
  • Antigens, Surface / metabolism*
  • Cell Adhesion Molecules
  • Chromosomes, Human, Pair 19*
  • Humans
  • Membrane Glycoproteins / biosynthesis
  • Molecular Sequence Data
  • Molecular Weight
  • Protein Processing, Post-Translational
  • Receptors, Virus / genetics
  • Receptors, Virus / metabolism*
  • Rhinovirus / metabolism*
  • Swainsonine
  • Transfection
  • Tunicamycin / pharmacology


  • Alkaloids
  • Antibodies, Monoclonal
  • Antigens, Surface
  • Cell Adhesion Molecules
  • Membrane Glycoproteins
  • Receptors, Virus
  • Tunicamycin
  • Swainsonine