Fiber consumption and all-cause, cardiovascular, and cancer mortalities: a systematic review and meta-analysis of cohort studies

Mol Nutr Food Res. 2015 Jan;59(1):139-46. doi: 10.1002/mnfr.201400449. Epub 2014 Dec 11.


The present meta-analysis aimed to investigate fiber consumption and all-cause mortality, and cause-specific mortality. MEDLINE and web of science database were searched for cohort studies published from inception to August 2014. Studies were included if they provided a hazard ratio (HR) and corresponding 95% CI for mortality in relation to fiber consumption.We found that, compared with those who consumed lowest fiber, for individuals who ate highest fiber, mortality rate was lower by 23% (HR, 0.77; 95% CI, 0.72-0.81) for CVD, by 17% (HR, 0.83; 95% CI, 0.74-0.91) for cancer, by 23% (HR, 0.77; 95% CI, 0.73-0.81) for all-cause mortality. For each 10 g/day increase in fiber intake, the pooled HR was estimated to be 0.89 (95% CI, 0.86-0.93) for all-cause mortality, 0.80 (95% CI, 0.72-0.88) for CHD mortality, and 0.66 (95% CI, 0.40-0.92) for IHD mortality, 0.91 (95% CI, 0.88-0.94) for cancer. Dietary fiber and CVD mortality showed a strong dose-response relation. Apparently, fiber consumption is inversely associated with all-cause mortality and CVD, IHD, cancer mortality.

Keywords: All-cause mortality; Cancer; Cardiovascular disease; Fiber; Meta-analysis.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Cardiovascular Diseases / mortality*
  • Databases, Factual
  • Dietary Fiber / administration & dosage*
  • Humans
  • Neoplasms / mortality*
  • Observational Studies as Topic
  • Risk Factors