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A Review on the Use of Cell Therapy in the Treatment of Tendon Disease and Injuries


A Review on the Use of Cell Therapy in the Treatment of Tendon Disease and Injuries

Jasmine Oy Ho et al. J Tissue Eng.


Tendon disease and injuries carry significant morbidity worldwide in both athletic and non-athletic populations. It is estimated that tendon injuries account for 30%-50% of all musculoskeletal injuries globally. Current treatments have been inadequate in providing an accelerated process of repair resulting in high relapse rates. Modern concepts in tissue engineering and regenerative medicine have led to increasing interest in the application of cell therapy for the treatment of tendon disease. This review will explore the use of cell therapy, by bringing together up-to-date evidence from in vivo human and animal studies, and discuss the issues surrounding the safety and efficacy of its use in the treatment of tendon disease.

Keywords: Tissue engineering; biocompatible materials; cell culture; cell therapy; tendon injury.

Conflict of interest statement

Declaration of conflicting interests: The authors declare that there is no conflict of interest.


Figure 1.
Figure 1.
Expression of growth factor during tendon healing phases.,, IGF-1: insulin-like growth factor 1; TGF-β: transforming growth factor β; PDGF: platelet-derived growth factor; bFGF: basic fibroblast growth factor; VEGF: vascular endothelial growth factor; BMP: bone morphogenetic protein; ECM: extracellular matrix.

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