Fertility sparing management and pregnancy in patients with granulosa cell tumour of the ovaries

J Obstet Gynaecol. 2015 May;35(4):331-5. doi: 10.3109/01443615.2014.968107. Epub 2014 Nov 10.


Granulosa cell tumours (GCTs) of the ovary are a rare entity among the neoplasms of gynaecological oncology. Deriving from the stroma of the ovary, GCTs are generally characterised by insidious growth, low malignancy potential and late recurrence. The standard treatment for these tumours is principally surgical, consisting of bilateral adnexectomy and hysterectomy. This is a narrative review of the current literature regarding the role of fertility sparing surgery in ovarian granulosa tumour. In the included studies, fertility sparing surgery was performed in 171 out of 350 patients. Recurrence rates ranged between 9.8-27.4%. Out of 131 patients, 15 achieved pregnancy. The data were limited regarding completion post-pregnancy surgery. Due to the fact that GCTs often affect younger ages, of crucial importance is the preservation of fertility by conserving the uterus and the contralateral ovary, while close monitoring is essential in order to achieve early identification and treatment of a possible recurrence. After completion of family planning, hysterectomy and salpingo-oophorectomy are recommended.

Keywords: Conservative treatment; granulosa cell tumour; young women.

Publication types

  • Review

MeSH terms

  • Female
  • Fertility Preservation / methods*
  • Granulosa Cell Tumor* / pathology
  • Granulosa Cell Tumor* / surgery
  • Gynecologic Surgical Procedures* / adverse effects
  • Gynecologic Surgical Procedures* / methods
  • Humans
  • Infertility, Female* / etiology
  • Infertility, Female* / therapy
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Staging
  • Organ Sparing Treatments / methods*
  • Ovarian Neoplasms* / pathology
  • Ovarian Neoplasms* / surgery
  • Pregnancy