Decolonization of children after incision and drainage for MRSA abscess: a retrospective cohort study

Clin Pediatr (Phila). 2015 May;54(5):445-50. doi: 10.1177/0009922814556059. Epub 2014 Nov 10.

Abstract

Background/purpose: Whether decolonization following incision and drainage (I&D) for methicillin-resistant Staphylococcus aureus (MRSA) abscess decreases repeat I&D and MRSA-positive cultures in children is unknown.

Materials/methods: Referral to the Pediatric Infectious Disease Service (PIDS) for decolonization was determined for eligible children (2003-2010), with outcomes studied over 12 months.

Results: We identified 653 children; 54 had been seen by PIDS. In the PIDS group, no patients (0/54, 0%) had a repeat I&D. In the no PIDS group 36/599 (6%) had a repeat I&D, P = .06. Logistic regression modeling for repeat I&D showed no significant effect, odds ratio = 0.29; 95% confidence interval = 0.04-2.15; P = .23. In the PIDS group, 3 patients (3/54, 5.6%) had a repeat MRSA-positive culture. In the no PIDS group, 58/599 (9.7%) had a positive repeat culture, P = .46. Logistic regression modeling for positive culture showed no significant effect (odds ratio = 0.55; 95% confidence interval = 0.17-1.81; P = .32).

Conclusions: We detected no statistically significant association between decolonization and repeat I&D or MRSA-positive culture.

Keywords: MRSA; abscess; bleach; decolonization; incision and drainage procedure; mupirocin.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abscess / surgery*
  • Administration, Intranasal
  • Anti-Bacterial Agents / administration & dosage
  • Baths / methods
  • Child
  • Child, Preschool
  • Cohort Studies
  • Disinfectants / administration & dosage
  • Drainage*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Mupirocin / administration & dosage*
  • Retrospective Studies
  • Risk Factors
  • Sodium Hypochlorite / administration & dosage*
  • Staphylococcal Infections / therapy*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Disinfectants
  • Mupirocin
  • Sodium Hypochlorite