An update on ABO-incompatible kidney transplantation

Transpl Int. 2015 Apr;28(4):387-97. doi: 10.1111/tri.12485. Epub 2014 Nov 24.


ABO-incompatible kidney transplantation is nowadays a well-established procedure to expand living donor transplantation to blood group incompatible donor/recipient constellations. In the last two decades, transplantation protocols evolved to more specific isohaemagglutinin elimination techniques and established competent antirejection protection protocols without the need of splenectomy. ABOi kidney transplantation associated accommodation despite isohaemagglutinin reappearance, C4d positivity of peritubular capillaries as well as the increased incidence of bleeding complications is currently under intense investigation. However, most recent data show excellent graft survival rates equivalent to ABO-compatible kidney transplantation outcome.

Keywords: ABO-incompatible kidney transplantation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ABO Blood-Group System*
  • Clinical Protocols
  • Complement C4 / immunology
  • Graft Rejection / prevention & control
  • Hemagglutinins / blood
  • Hemagglutinins / isolation & purification
  • Humans
  • Immunoglobulins, Intravenous
  • Immunologic Factors / therapeutic use
  • Kidney Transplantation*
  • Rituximab / therapeutic use
  • Transplantation Immunology*


  • ABO Blood-Group System
  • Complement C4
  • Hemagglutinins
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Rituximab