Abstract
A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp(2)-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon / chemistry
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Catalysis
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Dioxanes / chemistry*
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Hydrogen / chemistry
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Hydroxyl Radical / chemistry*
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Hydroxylation
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Oxidation-Reduction
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Palladium / chemistry*
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Quantum Theory
Substances
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Dioxanes
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Hydroxyl Radical
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Palladium
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Carbon
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Hydrogen
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1,4-dioxane