Primary central nervous system angiosarcoma: a case report and literature review

Neuropathology. 2015 Apr;35(2):184-91. doi: 10.1111/neup.12178. Epub 2014 Nov 11.


Angiosarcoma is a rare vascular malignant neoplasm that mainly occurs in skin and soft tissues. Intracranial localization is very rare and only a few cases have been reported. This report intends to present the clinical, radiological and pathological pictures of a primary central nervous system angiosarcoma along with a review of the literature. A 35-year-old woman presented at our institution with weakness and sensory disturbances of her right hand. Neuroimaging revealed a roughly round, hemorrhagic and moderately enhancing lesion in the left frontal posterior region. The tumor was totally removed under awake anesthesia and continuous monitoring of motor and language functions. Histopathology revealed an epithelioid angiosarcoma. Radical removal, followed by adjuvant radiotherapy and chemotherapy, is able to completely control the disease for a relatively long period.

Keywords: brain angiosarcoma; central nervous system tumor; neurosurgery; survival; treatment.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brain Neoplasms / pathology*
  • Child
  • Child, Preschool
  • Female
  • Hemangiosarcoma / pathology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Young Adult