The influence of dietary fat on liver fat accumulation

Nutrients. 2014 Nov 10;6(11):5018-33. doi: 10.3390/nu6115018.


Obesity is a known risk factor for the development of non-alcoholic fatty liver disease (NAFLD); however, it has been suggested that dietary fat, both amount and composition, may play a pivotal role in its development, independent of body fatness. Studies that have investigated the role of dietary fat on liver fat accumulation are reasonably sparse. We review here the available work that has investigated the impact of dietary fat: amount, composition and frequency, on liver fat accumulation in human observational and intervention studies. Overall, it would seem that total calorie consumption, rather than dietary fat composition, is an important factor in the development of fatty liver disease in humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adiposity
  • Diet
  • Dietary Fats / administration & dosage*
  • Energy Intake
  • Fatty Acids, Unsaturated / administration & dosage
  • Feeding Behavior*
  • Humans
  • Liver / metabolism
  • Liver / pathology
  • Non-alcoholic Fatty Liver Disease / physiopathology*
  • Obesity / complications
  • Triglycerides / metabolism


  • Dietary Fats
  • Fatty Acids, Unsaturated
  • Triglycerides