The spectrum of optic nerve disease in human immunodeficiency virus infection

Am J Ophthalmol. 1989 Apr 15;107(4):373-80. doi: 10.1016/0002-9394(89)90660-0.


We studied four patients with HIV-associated optic neuropathies. One had syphilitic optic perineuritis, which responded promptly and completely to penicillin therapy. The second had cytomegalovirus papillitis and visual acuity subsequently deteriorated to no light perception. The third showed varicella zoster optic neuritis, which improved after intravenous acyclovir treatment. The fourth patient developed cryptococcal retrobulbar neuritis and died shortly thereafter. Optic neuropathy was among the initial symptoms of HIV infection in two of the four cases.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Adult
  • Cryptococcosis / complications
  • Cytomegalovirus Infections / complications
  • Female
  • HIV Seropositivity
  • Herpes Zoster / complications
  • Humans
  • Male
  • Neurosyphilis / complications
  • Optic Neuritis / complications*
  • Papilledema / complications
  • Retinitis / complications