Abstract
In a study which involved 120 adult patients, the ED95 of suxamethonium was shown to be 0.51 mg/kg, using an electromyographic technique. Marked individual variation in response was noted, for example a dose of 0.3 mg/kg produced a range of blockade from 4%-90%. Body surface area was shown to be more significantly related to blockade than lean body mass or total body weight.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Body Surface Area
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Body Weight
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Cold Temperature
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Dose-Response Relationship, Drug
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Humans
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Middle Aged
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Muscle Contraction / drug effects
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Neuromuscular Junction / drug effects*
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Neuromuscular Junction / physiology
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Succinylcholine / administration & dosage
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Succinylcholine / pharmacology*
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Synaptic Transmission / drug effects
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Time Factors