The α-thalassemias

N Engl J Med. 2014 Nov 13;371(20):1908-16. doi: 10.1056/NEJMra1404415.


More than 100 varieties of α-thalassemia have been identified. Their geographic distribution and the challenges associated with screening, diagnosis, and management suggest that α-thalassemias should have a higher priority on global public health agendas.

Publication types

  • Review

MeSH terms

  • Child
  • Geography, Medical
  • Humans
  • Prenatal Diagnosis
  • Quality-Adjusted Life Years
  • alpha-Thalassemia* / diagnosis
  • alpha-Thalassemia* / genetics
  • alpha-Thalassemia* / therapy