Purpose: To describe a case of rapidly progressive diabetic retinopathy in a patient who is human immunodeficiency virus positive.
Methods: This is an observational case report.
Results: Fundus examination shows worsening of diabetic retinopathy with new vessels and vitreous hemorrhage in both eyes despite intense pan retinal photocoagulation.
Conclusion: For patients with diabetes, additional diagnosis of human immunodeficiency virus increases the challenge of managing diabetic retinopathy as proliferation can appear rapidly and tends to worsen in these patients.