Intradermal inactivated poliovirus vaccine: a preclinical dose-finding study

J Infect Dis. 2015 May 1;211(9):1447-50. doi: 10.1093/infdis/jiu624. Epub 2014 Nov 12.


Intradermal delivery of vaccines has been shown to result in dose sparing. We tested the ability of fractional doses of inactivated poliovirus vaccine (IPV) delivered intradermally to induce levels of serum poliovirus-neutralizing antibodies similar to immunization through the intramuscular route. Immunogenicity of fractional doses of IPV was studied by comparing intramuscular and intradermal immunization of Wistar rats using NanoPass MicronJet600 microneedles. Intradermal delivery of partial vaccine doses induced antibodies at titers comparable to those after immunization with full human dose delivered intramuscularly. The results suggest that intradermal delivery of IPV may lead to dose-sparing effect and reduction of the vaccination cost.

Keywords: dose sparing; immunogenicity; inactivated poliovirus vaccine; intradermal.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Dose-Response Relationship, Immunologic
  • Female
  • Injections, Intradermal / instrumentation
  • Poliovirus Vaccine, Inactivated / administration & dosage
  • Poliovirus Vaccine, Inactivated / economics
  • Poliovirus Vaccine, Inactivated / immunology*
  • Rats
  • Rats, Wistar


  • Antibodies, Viral
  • Poliovirus Vaccine, Inactivated