Changes in blood flow due to stented parent artery expansion in an intracranial aneurysm

Technol Health Care. 2015;23(1):9-21. doi: 10.3233/THC-140871.


Background: Stent placement is thought to obstruct the inflow of blood to an aneurysm. However, we introduced parent artery expansion and demonstrated that this may reduce the blood flow by the stent. In our previous study using idealized shapes, the results showed that flow reduction was greater than 22.2%, even if the expansion rate was only 6%. Furthermore, the parent artery expansion is predominantly caused by the effect of flow reduction as compared to that of flow reduction due to the obstruction of flow under stent placement. However, a realistic shape is complex and the blood flow also becomes complex flow. It is not understood whether the results of flow in the idealized shape are reflective of flow from a realistic 3D model. Therefore, we examined the effect of parent artery expansion using a realistic model.

Objective: The aim is to clarify the effects of parent artery expansion on inflow rate, wall shear stress, and oscillatory shear index.

Methods: We used a patient-specific geometry of a human internal carotid artery with an aneurysm. The geometry of parent artery expansion due to oversized stent constructed based on the voronoi diagram. We performed calculations in the unsteady-state situations using constructed models.

Results: The complexity of the flow in the aneurysm decreases in case of expanded parent artery. The inflow rate decreases by 33.6% immediately after parent artery expansion alone without a stent. The effect of the parent artery expansion on flow reduction is larger than that of the obstruction flow by stent placement. In addition, wall shear stress and oscillatory shear index on the aneurysm wall decrease by change in blood flow due to the parent artery expansion.

Conclusion: The effects of the parent artery expansion in a realistic aneurysm model with different stent lengths were evaluated on the basis of a numerical simulation. Although the flow was complex, the parent artery expansion with stent reduces the inflow to the aneurysm and wall shear stress and oscillatory shear index on the aneurysm. Therefore, we suggest that changes in the blood flow because of the parent artery expansion may be identified and, sometimes, is more effective than the obstruction flow due to the stent placement.

Keywords: Parent artery expansion; inflow rate; intracranial aneurysm; oscillatory shear index; stent; wall shear stress.

MeSH terms

  • Blood Flow Velocity / physiology
  • Blood Vessel Prosthesis Implantation*
  • Carotid Artery, Internal / diagnostic imaging
  • Carotid Artery, Internal / surgery*
  • Computer Simulation*
  • Humans
  • Intracranial Aneurysm / surgery*
  • Models, Cardiovascular
  • Pulsatile Flow
  • Radiography
  • Sensitivity and Specificity
  • Stents*
  • Stress, Mechanical