Evaluation of 9 rapid diagnostic tests for screening HIV infection, in Lomé, Togo

Med Mal Infect. 2014 Dec;44(11-12):525-9. doi: 10.1016/j.medmal.2014.10.007. Epub 2014 Nov 7.


Purpose: HIV rapid diagnostic tests (RDT) could be greatly contributive for a universal access to HIV diagnosis. However, according to the WHO, these tests need to be assessed before they can be used in routine.

Method and results: We assessed 9 RDT in routine clinical use between 2009 and 2013. The sensitivity and specificity observed for 7 tests were≥99% and≥98%, respectively: FIRST RESPONSE HIV1-2-O PMC Medical, India, GENIE Fast HIV 1-2 and GENIE™ III HIV(1/2) Bio-Rad, France, HIV TRI-DOT+Ag;J. Mitra, INDIA; SD BIOLINE HIV(1/2) 3.0 and SD BIOLINE HIV/SYPHILIS DUO Standard Diagnostic, Korea; and VIKIA HIV(1/2); BioMérieux, France. Two tests had performances inferior to WHO recommendations: INSTI HIV1/2 Biolytical Canada; sensitivity=97.8% and HEXAGON HIV HUMAN GmbH Germany; specificity=94.8%.

Conclusion: Seven of 9 RDT had excellent performances. Nevertheless, they can be used only after training staff, and taking into account national algorithm for their safe use.

Keywords: Dépistage; HIV; Rapid diagnostic test; Screening; Tests de diagnostic rapide.

Publication types

  • Evaluation Study

MeSH terms

  • AIDS Serodiagnosis / methods*
  • Algorithms
  • Early Diagnosis
  • False Negative Reactions
  • False Positive Reactions
  • HIV Antigens / immunology
  • HIV Infections / diagnosis*
  • HIV Infections / epidemiology
  • HIV-1 / immunology*
  • HIV-2 / immunology*
  • Humans
  • Reagent Kits, Diagnostic*
  • Reference Standards
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Time Factors
  • Togo / epidemiology


  • HIV Antigens
  • Reagent Kits, Diagnostic