Relationship between meconium staining and thymic stromal lymphopoietin

Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3016-8.

Abstract

Objective: Epithelium-derived thymic stromal lymphopoietin (TSLP), is a key pro-allergic cytokine that has recently been linked to chronic airway diseases. Our aim is to determine cord blood TSLP levels in pregnancies with meconium stained amniotic fluid.

Patients and methods: A total of 44 pregnant women with meconium stained amniotic fluid and a total of 44 healthy pregnant women were enrolled in the study. Cord blood TSLP was measured with TSLP ELISA Kit.

Results: We found no statistically significant differences between 2 groups in terms of age and parity. TSLP levels were found to be significantly higher in the cord blood of pregnant women with meconium stained amniotic fluid (104.3 ± 96.9 ng/ml) compared with the control group (63.2 ± 65.3 ng/ml) (p = 0.022).

Conclusions: It seems that TSLP is produced and released in response to meconium.

MeSH terms

  • Adult
  • Amniotic Fluid*
  • Cytokines / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fetal Blood / chemistry
  • Fetal Blood / metabolism*
  • Humans
  • Infant, Newborn
  • Meconium*
  • Pregnancy
  • Staining and Labeling
  • Young Adult

Substances

  • Cytokines
  • thymic stromal lymphopoietin