Treatment of ocular surface squamous neoplasia with topical Aloe vera drops

Cornea. 2015 Jan;34(1):87-9. doi: 10.1097/ICO.0000000000000296.


Purpose: To report a case of ocular surface squamous neoplasia (OSSN) that resolved with topical Aloe vera eye drop treatment.

Methods: A 64-year-old Hispanic woman with a lesion typical for OSSN in her left eye was followed up with multiple clinical examinations and ocular surface photographs to document changes over time with A. vera-based topical treatment.

Results: The patient refused biopsy of her lesion and traditional treatments and, instead, initiated using A. vera eye drops 3 times daily. At follow-up visits, the lesion was noted to regress until it finally resolved 3 months after commencing treatment. No additional topical medications were used, and she has remained tumor free for 6 years.

Conclusions: Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Topical
  • Allantoin / administration & dosage
  • Allantoin / therapeutic use*
  • Aloe / chemistry*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma in Situ / drug therapy*
  • Carcinoma in Situ / pathology
  • Conjunctival Neoplasms / drug therapy*
  • Conjunctival Neoplasms / pathology
  • Corneal Diseases / drug therapy*
  • Corneal Diseases / pathology
  • Female
  • Humans
  • Middle Aged
  • Ophthalmic Solutions
  • Parabens / administration & dosage
  • Parabens / therapeutic use
  • Phytotherapy*
  • Preservatives, Pharmaceutical / administration & dosage
  • Preservatives, Pharmaceutical / therapeutic use


  • Antineoplastic Agents
  • Ophthalmic Solutions
  • Parabens
  • Preservatives, Pharmaceutical
  • Allantoin
  • methylparaben