Retreatment and outcomes of recurrent intracranial vertebral artery dissecting aneurysms after stent assisted coiling: a single center experience

PLoS One. 2014 Nov 13;9(11):e113027. doi: 10.1371/journal.pone.0113027. eCollection 2014.

Abstract

Background and purpose: The retreatment of recurrent intracranial vertebral artery dissecting aneurysms (VADAs) after stent assisted coiling (SAC) has not yet been studied. The purpose of this study was to evaluate the strategies and outcomes for retreatment of recurrent VADAs after SAC.

Methods: Between September 2009 and November 2013, six consecutive patients presenting with recurrent intracranial VADAs after SAC were enrolled in this study. They were all male with age ranging from 29 to 54 years (mean age, 46.2 years). The procedures of treatments and angiographic and clinical follow-up were reviewed retrospectively. Retreatment modalities were selected individually according to the characteristics of recurrence. The outcomes of retreatment were evaluated by angiographic and clinical follow-up.

Results: Six patients with recurrent intracranial VADAs after SAC were retreated, with second SAC in three patients, coil embolization, double overlapping stents placement and endovascular occlusion with aneurysm trapping in one patient, respectively. Immediate angiographic outcomes of retreatment were: complete occlusion in three patients, nearly complete occlusion in two patients, and contrast medium retention in dissecting aneurysm in one patient. All cases were technically successful. No complications related to endovascular procedures occurred. Angiographic follow-up was available in all five patients treated with second SAC or double overlapping stents, which was complete occlusion in four patients, obliteration of parent artery in one patient, showing no recurrence at 4-11 months (mean: 8.6 months). Clinical follow-up was performed in all six patients at 11-51 months after initial endovascular treatment and at 9-43 months after retreatment. The mRS of last clinical follow-up was excellent in five patients and mild disability in only one patient.

Conclusions: Endovascular retreatment is feasible and effective for recurrent intracranial VADAs after SAC. Individualized strategies of retreatment should be enacted according to the characteristics and reasons for the recurrence.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cerebral Angiography*
  • Follow-Up Studies
  • Graft Occlusion, Vascular* / diagnostic imaging
  • Graft Occlusion, Vascular* / epidemiology
  • Graft Occlusion, Vascular* / surgery
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Stents*
  • Vertebral Artery Dissection / diagnostic imaging
  • Vertebral Artery Dissection / epidemiology
  • Vertebral Artery Dissection / surgery
  • Vertebral Artery* / diagnostic imaging
  • Vertebral Artery* / surgery

Grant support

This work was supported by the National Science Foundation of China (grant nos. 81220108007, 81171079 and 81471167) and Special Research Project for Capital Health Development (grant No. 2014-1-1071). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.