Physical function as a prognostic biomarker among cancer survivors

Br J Cancer. 2015 Jan 6;112(1):194-8. doi: 10.1038/bjc.2014.568. Epub 2014 Nov 13.


Background: We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors.

Methods: We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors.

Results: Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1 m s(-1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82-0.94); P<0.001, and HR: 0.88 (95% CI: 0.82-0.96); P=0.003, respectively).

Conclusions: Objectively measured physical function may predict mortality among cancer survivors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis*
  • Data Collection
  • Female
  • Humans
  • Male
  • Neoplasms / diagnosis*
  • Neoplasms / mortality*
  • Prognosis
  • Survivors
  • United States / epidemiology


  • Biomarkers, Tumor