Laparoscopic evacuation of mucinous ascites for palliation of pseudomyxoma peritonei

Ann Surg Oncol. 2015 May;22(5):1722-5. doi: 10.1245/s10434-014-4118-3. Epub 2014 Nov 14.


Introduction: Accumulation of mucinous ascites causes significant morbidity for patients with unresectable pseudomyxoma peritonei (PMP). The success of paracentesis for mucin evacuation is limited due to the presence of adhesions, disease burden, and the viscous nature of mucinous ascites. We sought to review our experience with laparoscopic evacuation of mucinous ascites for palliation of PMP.

Methods: Records were reviewed for patients who underwent laparoscopy for carcinomatosis secondary to appendix or colon cancer from July 2007 to January 2014. Of 123 patients, 10 were identified who underwent 17 laparoscopic procedures for palliative evacuation of mucinous ascites.

Results: All patients had primary appendiceal cancers and all presented with symptomatic ascites causing abdominal distension and bloating. Pneumoperitoneum was established with a Veress needle or 5-mm optical viewing trocar in the majority of cases (n = 11). In the remaining six cases, an open technique was used and a 10-mm Hasson trocar was placed. There were no trocar-related complications. The median volume of mucin evacuated was 2.0 liters (range 1.7-8.0). All procedures were done as same-day surgeries; no patients required hospitalization. All patients reported symptomatic improvement following the procedure. One patient experienced a grade 1 complication of persistent drainage from one incision, which was managed in the outpatient setting. The median follow-up for all pts was 9.1 months. The median time to recurrent symptoms requiring repeat intervention was 5.3 months.

Conclusions: Laparoscopic evacuation of mucinous ascites for select patients with PMP is feasible and results in significant, durable symptom control with minimal morbidity.

Publication types

  • Clinical Trial

MeSH terms

  • Adenocarcinoma, Mucinous / pathology
  • Adenocarcinoma, Mucinous / surgery
  • Adult
  • Aged
  • Appendiceal Neoplasms / pathology
  • Appendiceal Neoplasms / surgery
  • Ascites / pathology
  • Ascites / surgery*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / surgery
  • Drainage / methods*
  • Female
  • Follow-Up Studies
  • Humans
  • Laparoscopy / methods*
  • Male
  • Middle Aged
  • Mucins / metabolism*
  • Neoplasm Grading
  • Palliative Care*
  • Peritoneal Neoplasms / pathology
  • Peritoneal Neoplasms / surgery*
  • Pneumoperitoneum
  • Prognosis
  • Pseudomyxoma Peritonei / pathology
  • Pseudomyxoma Peritonei / surgery*
  • Retrospective Studies


  • Mucins