elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints

Science. 1989 Apr 7;244(4900):66-70. doi: 10.1126/science.2539641.


The myb-ets-containing acute leukemia virus, E26, transforms myeloblasts and erythroblasts in culture and causes a mixed erythroid and myeloid leukemia in chicks. Genes (ets-1, ets-2, and erg) with variable relatedness to the v-ets oncogene of the E26 virus have been identified, cloned, and characterized in several species. Two new members (elk-1 and elk-2) of the ets oncogene superfamily have now been identified. Nucleotide sequence analysis of the elk-1 cDNA clone revealed that this gene encodes a 428-residue protein whose predicted amino acid sequence showed 82% similarity to the 3' region of v-ets. The elk or related sequences appear to be transcriptionally active in testis and lung. The elk cDNA probe detects two loci in the human genome, elk-1 and elk-2, which map to chromosome regions Xp11.2 and 14q32.3, respectively. These loci are near the translocation breakpoint seen in the t(X;18) (p11.2;q11.2), which is characteristic of synovial sarcoma, and the chromosome 14q32 breakpoints seen in ataxia telangiectasia and other T cell malignancies. This suggests the possibility that rearrangements of elk loci may be involved in pathogenesis of certain tumors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Avian Leukosis Virus / genetics*
  • Base Sequence
  • Chick Embryo
  • Chickens
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA Probes
  • DNA-Binding Proteins*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Oncogenes*
  • Proto-Oncogene Proteins*
  • Rats
  • Retroviridae Proteins / genetics*
  • Retroviridae Proteins / isolation & purification
  • Transcription Factors*
  • Translocation, Genetic*
  • X Chromosome*
  • ets-Domain Protein Elk-1


  • DNA Probes
  • DNA-Binding Proteins
  • ELK1 protein, human
  • Elk1 protein, mouse
  • Elk1 protein, rat
  • Proto-Oncogene Proteins
  • Retroviridae Proteins
  • Transcription Factors
  • ets-Domain Protein Elk-1

Associated data

  • GENBANK/M25269