The cyclic AMP-mediated stimulation of cell proliferation

Trends Biochem Sci. 1989 Feb;14(2):67-71. doi: 10.1016/0968-0004(89)90046-7.


The role of cyclic AMP (cAMP) in the regulation of mammalian cell proliferation has been the subject of controversy. Negative control was demonstrated in the 1970s, but evidence of positive control in other cell types has been neglected. Recent evidence which demonstrates such a control in the yeast Saccharomyces cerevisiae has now made this concept acceptable.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division / drug effects*
  • Cyclic AMP / pharmacology*
  • Saccharomyces cerevisiae


  • Cyclic AMP