Gestational Hypertension and Preeclampsia in Living Kidney Donors

N Engl J Med. 2015 Jan 8;372(2):124-33. doi: 10.1056/NEJMoa1408932. Epub 2014 Nov 14.

Abstract

Background: Young women wishing to become living kidney donors frequently ask whether nephrectomy will affect their future pregnancies.

Methods: We conducted a retrospective cohort study of living kidney donors involving 85 women (131 pregnancies after cohort entry) who were matched in a 1:6 ratio with 510 healthy nondonors from the general population (788 pregnancies after cohort entry). Kidney donations occurred between 1992 and 2009 in Ontario, Canada, with follow-up through linked health care databases until March 2013. Donors and nondonors were matched with respect to age, year of cohort entry, residency (urban or rural), income, number of pregnancies before cohort entry, and the time to the first pregnancy after cohort entry. The primary outcome was a hospital diagnosis of gestational hypertension or preeclampsia. Secondary outcomes were each component of the primary outcome examined separately and other maternal and fetal outcomes.

Results: Gestational hypertension or preeclampsia was more common among living kidney donors than among nondonors (occurring in 15 of 131 pregnancies [11%] vs. 38 of 788 pregnancies [5%]; odds ratio for donors, 2.4; 95% confidence interval, 1.2 to 5.0; P=0.01). Each component of the primary outcome was also more common among donors (odds ratio, 2.5 for gestational hypertension and 2.4 for preeclampsia). There were no significant differences between donors and nondonors with respect to rates of preterm birth (8% and 7%, respectively) or low birth weight (6% and 4%, respectively). There were no reports of maternal death, stillbirth, or neonatal death among the donors. Most women had uncomplicated pregnancies after donation.

Conclusions: Gestational hypertension or preeclampsia was more likely to be diagnosed in kidney donors than in matched nondonors with similar indicators of baseline health. (Funded by the Canadian Institutes of Health Research and others.).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / epidemiology*
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Kidney Transplantation*
  • Living Donors*
  • Nephrectomy
  • Odds Ratio
  • Ontario / epidemiology
  • Postpartum Hemorrhage / epidemiology
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Outcome / epidemiology
  • Premature Birth / epidemiology
  • Retrospective Studies